Scientific
advances in cell biology, microfabrication and microfluidics have led to the
development of Organ-on-Chips (OOCs). OOCs are microfluidic 3D cell culture
devices that closely mimic the key physiological functions of body organs.
These chips are not designed to biomimic an entire organ, but simulate the
physiology of a single functional unit of an organ system.
TBRC’s
report covers the various segments in the market, such as lung on a chip, heart
on a chip, the microarray market, lab-on-a-chip market, etc.
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The Biochip Market
The process of drug discovery and development begins with
the identification of structure and function of molecular or cellular targets
that participate in the pathophysiology of disease. In the past, a small number
of molecules with therapeutic potential were discovered serendipitously;
however, recent advances in genetics and proteomics research have allowed the
development of a vast number of compounds for various diseases. The
availability of high-throughput techniques has facilitated rapid screening of
these molecules to test for biological activity using in-vitro assays.
North America accounted for about 60% of the global market
for organ on a chip in 2017. The USA accounts for the dominant share of the
North American market. This is mainly due to the presence of several potential
end-users, including major pharmaceutical giants such as Pfizer,
GlaxoSmithKline, Johnson & Johnson, and major research organizations.
The provision of high-scale funding by several US government
organizations including National Institutes of Health (NIH) and Defense
Advanced Research Projects Agency (DARPA) also supports research in the market
in the USA.
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North America will continue to account for the largest share
of the global OOC market during the forecast period. North America is the
headquarters for many pharmaceutical companies and research organizations. The
presence of multiple end-users increases the scope for sales collaborations
thus increasing the prospects of market growth. For instance, out of the three
disclosed companies which have signed collaborations with CN Bio since the
beginning of 2015, two are US-based companies (Alnylam Pharmaceuticals Inc. and
Isis Pharmaceuticals Inc.) Another example of a major collaboration is between
J&J and Emulate Bio signed in June 2015.
Organs on chips manufacturing companies included in the
report are CN Bio Innovations,
Emulate, TissUse, Mimetas, Hurel, Nortis, InSphero and Tara Biosystems.
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